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IMM-H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral isch
[会议论文] 作者：ZUO Wei,CHEN Nai-hong,
来源：第十六届全国神经精神药理学学术会议 年份：2014
OBJECTIVE Ischemic stroke is currently treated with thrombolytic therapy with a drawback to induce hemorrhagic transformation if applied beyond its relatively narrow treatment time window.The present...
[会议论文] 作者：ZHENG Mou,YUAN Yu-he,CHEN Nai-hong,
来源：第十六届全国神经精神药理学学术会议 年份：2014
Parkinsons disease (PD) is a chronic progressive neurodegenerative disease which was first described in 1817, affecting 1% of population over 60 years old.And it is a part of a subset of diseases clas...
Neuroprotective role and its mechanism of IMM-H004 in transient global cerebral ischemia/reperfusion
[会议论文] 作者：ZHANG Zhao,CHU Shi-feng,CHEN Nai-hong,
来源：第十七届全国神经精神药理学学术会议 年份：2016
OBJECTIVE To investigate the neuroprotective effect and its mechanism of IMM-H004,a 3-piperazinylcoumarin compound derived from coumarin,after transient global ischemia/reperfusion(TGCI/R).METHODS Adu...
[会议论文] 作者：CHEN Jiao,WANG Zhen-zhen,ZUO Wei,CHEN Nai-hong,
来源：中国药理学会第十三次全国学术大会 年份：2015
Depression is a leading cause of disability worldwide.However the biological and molecular mechanisms underlying this disorder remain to be unknown.Stress is a disposing factor in the development of d...
[会议论文] 作者：SONG Xiu-yun,XU Shuang,HU Jin-feng,Chen Nai-hong,
来源：中国药理学会第十三次全国学术大会 年份：2015
Biliary cholesterol may contribute to the formation of cholesterol gallstones, regulation of these levels could be a useful therapeutic strategy for gallstones disease.Piperine (PA) is a potential cho...
Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following foc
[会议论文] 作者：KONG Ling-lei,DU Guan-hua,HU Jin-feng,YUAN Yu-he,CHEN Nai-hong,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
OBJECTIVE To investigate the role of chemokine-like factor 1 (CKLF1), a novel C-C chemokine, on brain-blood barrier(BBB) integrity in rat focal cerebral isc...
Inhibition of chemokine-like factor 1 improves bloodbrain barrier dysfunction in rats following foca
[期刊论文] 作者：KONG Ling-lei,HU Jin-feng,YUAN Yu-he,CHEN Nai-hong,DU Guan-hua,,
来源：中国药理学与毒理学杂志 年份：2016
OBJECTIVE To investigate the role of chemokine-like factor 1(CKLF1),a novel C-C chemokine,on brain-blood barrier(BBB)integrity in rat focal cerebral ischemia an...
Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following foc
[会议论文] 作者：KONG Ling-lei,HU Jin-feng,YUAN Yu-he,CHEN Nai-hong,DU Guan-hua,
来源：中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 年份：2016
OBJECTIVE To investigate the role of chemokine-like factor 1 (CKLF1), a novel C-C chemokine, on brain-blood barrier(BBB) integrity in rat focal cerebral ischemia and reperfusion model....
[会议论文] 作者：WANG Zhen-zhen,YUAN Yu-he,HAN Ning,ZHANG Yi,CHEN Nai-hong,
来源：中国药理学会第十三次全国学术大会 年份：2015
Aim To investigate the role of CKLF1 in SHSYSY cell migration and its molecular regulatory mechanism.Methods SHSY5Y cells were stimulated with CKLF1 for 0.5, 2, 8 and 24 h, respectively.The migration...
[会议论文] 作者：SUN Jian-dong,LIU Yan,YUAN Yu-he,LI Jing,CHEN Nai-hong,
来源：第十五届中国神经精神药理学学术会议 年份：2012
Growing evidence has implicated glial anomalies in the pathophysiology of major depression disorder (MDD).Gap junctional communication is a main determinant of astrocytic function.However, it is uncle...
[会议论文] 作者：CHEN Jiao,WANG Zhen-zhen,ZUO Wei,ZHANG Shuai,CHU Shi-feng,CHEN Nai-hong,
来源：第十七届全国神经精神药理学学术会议 年份：2016
Major depression is thought to originate from maladaptation to adverse events,particularly when impairments occur in mood-related brain regions.Hypothalamus...
[会议论文] 作者：ZHANG Yi,WANG Zhen-zhen,SUN Hong-mei,LI Ping,LI Yun-feng,CHEN Nai-hong,
来源：第十六届全国神经精神药理学学术会议 年份：2014
Depression is the most common non-motor syndrome of Parkinsons disease (PD).Recent clinical trials have evaluated effectiveness of traditional Chinese medicine (TCM) in the treatment of depression in...
[会议论文] 作者：WANG Zhen-zhen,YUAN Yu-he,ZHANG Yi,WANG Xiao-feng,CHU Shi-feng,HAN Ning,CHEN Nai-Hong,
来源：第十六届全国神经精神药理学学术会议 年份：2014
OBJECTIVE To investigate the potential roles of chemokine-like factor 1 (CKLF1), a newly cloned chemotactic cytokine, in the cortical neuronal migration.METHODS The organotypic brain slice cultures at...
Targeted overexpression of α-synuclein by rAAV2/1vectors induces progressive nigrostriatal degenerat
[会议论文] 作者：MOU Zheng,SONG Lian-kun,MA Kai-li,YUAN Yu-he,SONG Xiu-yun,NIU Fei,HAN Ning,CHEN Nai-hong,
来源：中国药理学会第十三次全国学术大会 年份：2015
Aim αsynuclein genes including its mutations, duplication and triplication are the first identified genetic factor involved in the progress of PD.And αsynuclein (tsyn) is the main component in patholo...
Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor
[会议论文] 作者：GAO Yan,CHU Shi-feng,ZHANG Zhao,XIA Cong-yuan,HENG Yang,ZHANG Mei-jin,HU Jin-feng,CHEN Nai-hong,
来源：中国药理学会第十三次全国学术大会 年份：2015
Aim Ginseng is the dried root of Panax ginseng C.A.Mayer.Since ancient times, ginseng has been used as one kind of treatment drug or tonic in China and even other eastern countries like Korea and Japa...
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