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目的分析血清胃蛋白酶原(PG)水平与幽门螺杆菌(Hp)感染的关系。方法体检成人3480例,采用HG-IRIS13 C红外光谱仪测定Hp感染,时间分辨荧光免疫法测定血清PGⅠ和PGⅡ水平。以血清PGⅠ、PGⅠ/Ⅱ均降低视为PG(+)。结合Hp检测结果,人群胃癌患病风险分四组:A组Hp(-)PG(-)、B组Hp(+)PG(-)、C组Hp(+)PG(+)、D组Hp(-)PG(+)。结果人群Hp阳性率44.94%,血清PGⅠ为(151.50±60.83)μg/L,PGⅡ为(12.97±8.28)μg/L,PGⅠ/Ⅱ比值13.96±6.59。Hp阳性组血清PGⅠ、PGⅡ水平高于Hp阴性组,PGⅠ/Ⅱ比值低于Hp阴性组(P<0.05)。胃癌患病风险分级:A组1884例(54.14%),B组1553例(44.63%),C组11例(0.32%),D组32例(0.92%)。结论血清PG水平与Hp感染关系密切。
Objective To analyze the relationship between serum pepsinogen (PG) level and Helicobacter pylori (Hp) infection. Methods A total of 3480 adult patients were examined with HG-IRIS13 C infrared spectroscopy. Serum PGⅠ and PGⅡ levels were determined by time-resolved fluorescence immunoassay. Serum PG Ⅰ, PG Ⅰ / Ⅱ were reduced as PG (+). Hp (+) PG (-), B (Hp (+) PG (-)), C (Hp (-) PG (+). Results The positive rate of Hp was 44.94%, the serum PGⅠ was (151.50 ± 60.83) μg / L, the PGⅡ was (12.97 ± 8.28) μg / L and the PGⅠ / Ⅱ ratio was 13.96 ± 6.59. The serum PGⅠ and PGⅡ levels in Hp positive group were higher than those in Hp negative group, and the PG Ⅰ / Ⅱ ratio was lower than that in Hp negative group (P <0.05). The prevalence of gastric cancer was 1884 (54.14%) in group A, 1553 (44.63%) in group B, 11 (0.32%) in group C and 32 (0.92%) in group D. Conclusion Serum PG levels are closely related to Hp infection.