INTRODUCTIONEndothelins (ETs) has a potent and sustained vasoconstrictive effect on a variety of blood vessels.The vascular smooth muscle cell (VSMC) is the target for ETs. VSMC of the whole body contains endothelin receptor (ETR)[1]. A great number of experiments have shown that three distinct complementary DNAs of ETR have been identified i. e., endothelin A receptor (ETA receptor),endothelin B receptor ( ETB receptor ) and endothelin C receptor (ETc receptor). ETA receptor was expressed in VSMC responsible for the contraction[2]. The aim of this study is to confirm the effects of endotoxin on the activity of ETR, and the transcription and expression of ETA receptor mRNA in hepatic and intestinal tissues.