论文部分内容阅读
支气管哮喘是与血小板活化因子(PAF)有关的典型呼吸道疾病之一,成人呼吸窘迫综合征(ARDS)亦与PAF相关。本文阐述PAF与此两种疾病的相关性。一、支气管哮喘支气管哮喘为可逆性气道狭窄性疾病,气道狭窄的最重要原因为支气管收缩,此外,气道过敏亦是支气管哮喘的特征,PAF为可致支气管收缩、诱导气道过敏的物质。1.气道中产生的PAF:体外试验表明、PAF通过抗IgE、抗原酵母多糖及钙离子载体等刺激可从嗜碱性粒细胞、肥大细胞、中性粒细胞、嗜酸性粒细胞、血小板及巨噬细胞中释放。已知肺中含有大量上述细胞,如摘出致敏肺用抗原刺激后,证明灌注液中有PAF存在。PAF代谢迅速,在人体内难以测定。仲村等报道,于吸
Bronchial asthma is one of the typical respiratory diseases associated with platelet-activating factor (PAF). Adult respiratory distress syndrome (ARDS) is also associated with PAF. This article describes the relationship between PAF and these two diseases. First, bronchial asthma Bronchial asthma is reversible airway stenosis, airway stenosis is the most important reason for bronchoconstriction, in addition, airway allergy is also a characteristic of bronchial asthma, PAF can be caused by bronchoconstriction, induced airway allergy substance. 1. PAF produced in the airways: In vitro tests have shown that PAF can be stimulated by anti-IgE, antigenic zymosan and calcium ionophores and the like from the basophils, mast cells, neutrophils, eosinophils, platelets, Release from the phagocytes. It is known that a large amount of the above-mentioned cells are contained in the lungs, and the presence of PAF in the perfusate is demonstrated after stimulation of antigen-extracted lungs with antigen. PAF metabolizes quickly and is difficult to measure in the human body. Nakamura and other reports, in the suction