血压升高和血脂是心血管疾病的主要危险因子。抗高血压治疗已表明在很大程度上能降低与高血压有关疾病的发病率。然而在以前进行的早期预防性治疗的试验中冠心病的发病率并未显著降低。对此现象已提出的解释是:β受体阻断剂和利尿药对血脂的不良作用抵销了部分与降压有关的有利作用。现在钙拮抗剂越来越多地用于高血压的治疗,基本上没有发现对血脂的不良作用。但是 Hypertension and lipids are the major risk factors for cardiovascular disease. Antihypertensive therapy has shown to a large extent reduce the incidence of hypertension-related diseases. However, the incidence of coronary heart disease has not been significantly reduced in previous trials of early prophylactic treatment. An explanation for this phenomenon has been suggested: The adverse effects of beta blockers and diuretics on blood lipids offset some of the beneficial effects associated with antihypertensive effects. Calcium antagonists are now increasingly being used for the treatment of hypertension and little or no adverse effects on blood lipids have been found. but