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目的:探讨血清胱抑素C(Cys C)、血肌酐(Scr)、尿素氮(Urea)在肺炎支原体相关性肾炎(MPAN)诊断中的价值，为MPAN的早期诊断提供参考依据。方法:选取2015年6月至2017年6月广东省妇幼保健院儿科收治的50例MPAN患者为观察组，50例同期在该院体检健康者为对照组，按内生肌酐清除率高低将观察组分为A组、B组、C组，比较对照组及观察组的血清Cys C、Scr及Urea水平，比较观察组中A组、B组、C组患者Cys C、Scr及Urea水平及异常率。结果:观察组中A组、B组、C组患者Cys C水平分别为(1.25±0.13)mg/L、(1.74±0.34)mg/L、(3.72±1.33)mg/L，Scr水平分别为(150.46±21.09)μmol/L、(268.57±108.68)μmol/L、(476.66±91.25)μmol/L，Urea水平分别为(8.75±1.09)mmol/L、(11.49±1.50)mmol/L、(17.68±2.92)mmol/L，对照组中Cys C、Scr及Urea分别为(0.74±0.23)mg/L、(56.86±42.36)μmol/L、(3.43±1.33)mmol/L，与对照组相比，观察组各组的Cys C水平均高于对照组，差异有统计学意义(n t＝20.379、22.991、13.128，均n P<0.05)；与对照组相比，观察组各组的Scr水平均高于对照组，差异均有统计学意义(n t＝21.768、21.423、43.640，均n P<0.05)；与对照组相比，观察组各组的Urea水平均高于对照组，差异均有统计学意义(n t＝37.501、33.404、46.661，均n P<0.05)；同时随着肾功能损伤程度加重，Cys C、Scr、Urea水平呈递增趋势。观察组中A组、B组、C组患者Cys C、Scr、Urea两两比较，C组Cys C、Scr及Urea水平均高于B组，差异均有统计学意义(n t＝9.737、9.333、12.389，均n P<0.05)；C组Cys C、Scr及Urea水平均高于A组，差异均有统计学意义(n t＝19.880、35.753、27.127，均n P<0.05)；B组Cys C、Scr及Urea水平均高于A组，差异均有统计学意义(n t＝13.207、11.163、11.177，均n P<0.05)。在肾功能损伤早期即肾功能不全代偿期，Cys C异常率(62.07%)显著高于Scr及Urea的异常率(10.34%、24.13%)。n 结论:MPAN患者血清Cys C、Scr、Urea水平均高于健康人群，肾功能损害程度越严重，血清Cys C、Scr、Urea水平越高，可为MPAN的诊断、病情预测及辅助诊断标准提供临床参考，尤其Cys C对MPAN的早期诊断更有重要意义。“,”Objective:To discuss the clinical value of cystatin C (Cys C), serum creatinine (Scr) and serum urea nitrogen (Urea) in the diagnosis of mycoplasma pneumoniae-associated nephritis (MPAN), thus to provide reference basis for MPAN diagnosis.Methods:From June 2015 to June 2017, 50 patients with MPAN who were treated in Women and Children Hospital of Guangdong Province were selected as observation group, and 50 healthy children who underwent physical examination in the hospital during the same period were selected as control group.The observation group was divided into group A, group B and group C according to the level of endogenous creatinine clearance rate.The serum levels of Cys C, Scr and Urea were compared between the control group and the observation group.The levels of Cys C, Scr and Urea and the abnormal rate in group A, group B and group C were compared.Results:In the observation group, the Cys C levels of groups A, B and C were (1.25±0.13)mg/L, (1.74±0.34)mg/L, (3.72±1.33)mg/L, respectively, the Scr levels were (150.46±21.09)μmol/L, (268.57±108.68)μmol/L, (476.66±91.25)μmol/L, respectively, the Urea levels were (8.75±1.09)mmol/L, (11.49±1.50)mmol/L and (17.68±2.92)mmol/L, respectively.In the control group, the Cys C, Scr and Urea levels were (0.74±0.23)mg/L, (56.86±42.36)mol/L, (3.43±1.33)mmol/L, respectively.Compared with the control group, the Cys C level of the observation group was higher, the differences were statistically significant (n t=20.379, 22.991, 13.128, all n P<0.05). The Scr level of each group in the observation group were higher than those of the control group, the differences were statistically significant (n t=21.768, 21.423, 43.640, all n P<0.05). The Urea level of each group in the observation group was higher than that of the control group, the differences were statistically significant (n t=37.501, 33.404, 46.661, all n P<0.05). The levels of Cys C, Scr and Urea in group C were higher than those in group B, the differences were statistically significant (n t=9.737, 9.333, 12.389, all n P<0.05). The Cys C, Scr and Urea levels in group C were higher than those in group A, the differences were statistically significant (n t=19.880, 35.753, 27.127, all n P<0.05). The Cys C, Scr and Urea levels in group B were higher than those in group A, the differences were statistically significant (n t=13.207, 11.163, 11.177, all n P<0.05). In the early stage of renal function injury, namely renal insufficiency compensation stage, the abnormal rate of Cys C(62.07%) was significantly higher than that of Scr and Urea(10.34%, 24.13%).n Conclusion:The serum Cys C, Scr and Urea levels of MPAN patients are all higher than healthy people.The more severe the renal function damage is, the higher the serum Cys C, Scr and Urea levels are, which can provide clinical reference for the diagnosis, disease prediction and auxiliary diagnostic criteria of MPAN.In particular, Cys C is more important for the early diagnosis of MPAN.