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新生儿感染是引起新生儿发病及死亡的重要原因,尤其是极低出生体重早产儿。新生儿由于免疫系统发育不成熟,较容易受到病原体的入侵,引发不同的感染性疾病。在我国新生儿感染中,感染性肺炎最为常见,其次是败血症和肠道感染,严重损害新生儿的健康。由于多肽较强的广谱性抗菌作用以及进化上的保守性使其成为广泛研究的热点。已有多项研究证实多肽在新生儿抗感染中的作用,并且能够抑制耐药性细菌,有望为新生儿抗感染治疗提供新方法。本文将对多肽在新生儿感染引发的肺炎、败血症、坏死性小肠结肠炎中的研究进展做进一步阐述。
Neonatal infection is an important cause of neonatal morbidity and mortality, especially in very low birth weight preterm infants. Neonates are immature due to the immune system, are more susceptible to the invasion of pathogens, triggering different infectious diseases. In our country neonatal infection, the most common infectious pneumonia, followed by sepsis and intestinal infections, severely damaged the health of newborns. Due to the strong broad-spectrum antibacterial activity of the polypeptide and its evolutionary conservation, it has become a hot topic of extensive research. A number of studies have confirmed the role of peptides in neonatal infection and their ability to inhibit drug-resistant bacteria, promising to provide new approaches to anti-infective treatment in newborns. This article will further elucidate the research progress of the polypeptide in pneumonia, sepsis and necrotizing enterocolitis caused by neonatal infection.