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利用ＲＮＡ狭缝杂交技术，观察了肾素基因在体外培养的乳鼠心肌细胞与非心肌细胞的表达以及血管紧张素Ⅱ（ＡｎｇⅡ）对其表达的影响，同时还观察了血管紧张素转换酶抑制剂－卡托普利对这两类细胞ＤＮＡ合成的作用。结果表明：这两类细胞中均有肾素基因的表达；ＡｎｇⅡ对其表达具有负性调节作用。而卡托普利可抑制非心肌细胞的３Ｈ－ＴｄＲ掺入率且呈明显的剂量依赖关系，但对心肌细胞３Ｈ－ＴｄＲ掺入率只在效高浓应时有抑制作用。以上结果提示：心肌与非心肌细胞中均有ＲＡＳ的存在，并于细胞水平上被隔室化，对细胞生长具有不同的调节作用。
The effect of renin gene on the expression of cardiomyocytes and non-cardiomyocytes and the expression of angiotensin Ⅱ (AngⅡ) in neonatal rat cardiomyocytes was observed by RNA slit hybridization. At the same time, the effect of angiotensin converting enzyme inhibition Effect of captopril on DNA synthesis in these two types of cells. The results showed that both types of cells have renin gene expression; Ang Ⅱ negatively regulate its expression. However, captopril inhibited 3H-TdR incorporation in non-cardiomyocytes in a dose-dependent manner. However, 3H-TdR incorporation rate in cardiomyocytes was inhibited only when the concentration of 3H-TdR was high. The above results suggest that both RAS exists in both myocardium and non-cardiomyocytes and is compartmentalized at the cellular level, which have different regulatory effects on cell growth.