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目的 了解新生儿窒息后血清胰岛素水平的动态变化及临床意义。方法 采用放射免疫法测定43例不同程度窒息后早产儿和足月儿出生后第1、3、7天血清胰岛素水平。结果 轻度和重度窒息后足月儿及早产儿出生后第1、3、7天的血清胰岛素水平差异均有显著性意义 (均P<0.01) ,第1天明显高于第3天和第7天 (均P<0.01或<0.05) ;所有患儿至窒息后第3天血清胰岛素水平均恢复到正常水平 ;重度窒息足月儿出生后第1天 ,血清胰岛素水平明显高于轻度窒息足月儿 (P<0.05)。结论 新生儿窒息后可引起暂时性高胰岛素血症。
Objective To investigate the dynamic changes of serum insulin level and its clinical significance after neonatal asphyxia. Methods Serum insulin levels of 43 preterm infants with asphyxia and full-term infants at postnatal days 1, 3 and 7 were measured by radioimmunoassay. Results There was significant difference in serum insulin levels on the 1st, 3rd and 7th day after birth in mild term and severe asphyxia (all P <0.01), and obviously higher on the first day than on the third day and the seventh day Day (all P <0.01 or <0.05). All children returned to normal levels of serum insulin on the third day after asphyxia. On the first day after birth, the level of serum insulin was significantly higher than that of mild suffocation Month children (P <0.05). Conclusion Neonatal asphyxia can cause transient hyperinsulinemia.