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目的探讨根据激光切削深度选择丝裂霉素C(MMC)作用时间预防LASEK术后角膜上皮下雾状浑浊(haze)形成的效果。方法LASEK86例(168眼),术中用0.02%丝裂霉素C滤纸片覆盖于激光切削后的基质床上,切削深度70～100μm者浸润15s,100～130μm者浸润25s,130～160μm者浸润35s,160μm以上者浸润45s。观察术后1月、3月、6月时的视力、屈光状态、haze形成情况及并发症。结果165眼术后6d上皮完全愈合;3眼上皮愈合延迟。术后6月非矫正视力≥0.5者为100.0%,≥1.0者97.6%;术后屈光状态等效球镜度在预期矫正度数±0.50D以内者98.8%,±1.00D以内者100.0%。不同的切削深度经MMC处理后haze的出现在各组间无显著差异。结论LASEK术中应用0.02%MMC并根据切削深度选择作用时间能有效地抑制haze的形成。
Objective To investigate the effect of mitomycin C (MMC) on the formation of haze in corneal epithelium after LASEK. Methods LASEK86 cases (168 eyes) were treated with 0.02% mitomycin C filter paper in laser cutting bed. The depth of penetration was 70 ~ 100μm and the infiltration rate was 25 ~ 130 ~ 160μm 35s, 160μm or more infiltration 45s. Visual acuity, refractive status, haze formation and complications at 1 month, 3 months and 6 months after operation were observed. Results 165 eyes were completely healed after 6 days and 3 eyes had delayed healing. The non-corrected visual acuity≥0.5 in 6 months after operation was 100.0%, and the rate of ≥1.0 was 97.6%. The equivalent spherical scope of refraction after operation was 98.8% within ± 0.50D and 100.0% within ± 1.00D. The presence of haze after MMC treatment at different depths of cut showed no significant differences among the groups. Conclusion The application of 0.02% MMC in LASEK surgery and the selection of action time according to the depth of cut can effectively inhibit the formation of haze.