目前胞浆内精子注射(ICSI)被广泛用于治疗男性不育症,并明显改善了受精率和妊娠率。但由此导致的潜在性后代健康问题,受到普遍的关注。 曾有报道,ICSI与后代的性染色体异常发生率高有关。但后来有研究指出,目前还不能确定这种关系。在大量的ICSI病例中,染色体异常发生率与一般人群是相似的。Plachot等发现ICSI和常规体外受精(IVF)的未受精卵中异倍体和染色体断裂发生率是相似的,但来自IVF的未受精卵中二倍体多于来自ICSI的,而ICSI后的未受精卵中发 Currently intracytoplasmic sperm injection (ICSI) is widely used to treat male infertility and significantly improves fertility and pregnancy rates. However, the health problems of potential offspring caused by this have received widespread attention. It has been reported that ICSI is associated with a high incidence of sex chromosome abnormalities in future generations. However, later studies pointed out that it is not yet possible to determine this relationship. In a large number of ICSI cases, the incidence of chromosomal abnormalities is similar to the general population. Plachot et al. Found that the incidence of aneuploidy and chromosome breakage was similar in ICSI and conventional in vitro fertilization (IVF) unfertilized eggs, but more diploids were found in unfertilized eggs from IVF than from ICSI but not after ICSI Fertilized eggs in hair