背景:微创技术的发展极大的降低了脊柱转移瘤手术并发症,微创治疗技术方法中以椎体骨水泥增强、射频消融联合椎体成形、术中放疗联合椎体成形三大类技术为主。目的总结研究上述三类微创治疗方法的研究进展以及优缺点等。方法:利用网络以“脊柱转移瘤、椎体成形、射频消融、放射治疗”等为关键词查阅大量数据,并从中选取适合研究的典型病例进行总结研究。结果与结论:骨水泥增强技术临床效果较好,能够快速缓解患者疼痛,增强了椎体稳定性,有效率高达80%,但是骨水泥不能抑制肿瘤细胞的繁殖,治疗效果十分有限;射频消融联合椎体成形虽然能够杀伤肿瘤细胞,但是不能增强椎体稳定性。由此可见,两种技术各有利弊,若将其结合,即在术中进行放疗或者向病灶植入含放射性且对人体并无较大伤害的物质,理论上来说既能增强稳定性,又能杀伤肿瘤细胞,但是由于该技术是近几年的新兴技术,病例较少,而且缺乏长期跟踪调查,目前并不能认为联合治疗优于单纯治疗。由于每位患者患病情况不尽相同,经联合治疗后患者出现的不良反应也不同,尤其是出现骨水泥渗漏的风险较高,容易导致神经压迫加重,甚至神经损伤。由此观之,目前还没有一种较为完善合理的微创治疗脊柱转移瘤的方法。 BACKGROUND: The development of minimally invasive technique greatly reduces the surgical complications of spinal metastases. The techniques of minimally invasive treatment are three types of techniques: enhanced vertebral bone cement, radiofrequency ablation combined with vertebroplasty, intraoperative radiotherapy and vertebroplasty Mainly. Objective To summarize the research progress, advantages and disadvantages of the above three methods of minimally invasive treatment. Methods: We used the internet to search a large amount of data with key words such as “Spinal Metastases, Vertebroplasty, Radiofrequency Ablation, Radiotherapy” and so on. We selected the typical cases that were suitable for the study and summarized them. RESULTS AND CONCLUSION: The bone cement augmentation technique has a good clinical effect, can quickly relieve the patient’s pain and enhance the stability of the vertebral body, with an effective rate of up to 80%. However, the cement can not inhibit the propagation of the tumor cells and the treatment effect is very limited. RFA Although vertebroplasty can kill tumor cells, it can not enhance vertebral stability. Thus, the two technologies have their own advantages and disadvantages, if combined, that is, intraoperative radiotherapy or implantation of radioactive lesions containing no significant harm to the human body, in theory, both to enhance stability, and Can kill tumor cells, but because of the technology is a new technology in recent years, fewer cases, and the lack of long-term follow-up survey, the current combination can not be considered better than simple treatment. As each patient’s condition varies, the adverse reactions experienced by the combination therapy are different, especially the risk of bone cement leakage is higher, easily lead to increased nerve compression, and even nerve injury. From this point of view, there is no more perfect and reasonable minimally invasive treatment of spinal metastases.