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目的了解天津市健康人群麻疹、风疹、流行性腮腺炎抗体水平,评价疫苗接种需求。方法2007年3月采集0~57岁健康人群608人份血样品,用ELISA方法定量检测麻疹、风疹、流行性腮腺炎IgG抗体水平。运用直线相关分析抗体阳性率,保护率GMC与疾病发病率之间的关系,P<0.05为差异有统计学意义。结果麻疹、风疹和流行性腮腺炎疫苗接种率分别为70.39%、16.78%和12.34%;抗体阳性率分别为91.78%,65.79%和73.52%;抗体几何平均浓度(GMC)分别为2 488.10 IU/L、200.4 IU/ml和759.91 U/ml。麻疹抗体阳性率,保护率与发病率存在明显相关关系(P<0.01),而GMC与麻疹发病率没有显著性相关;风疹和流行性腮腺炎抗体阳性率、GMC与发病率无相关关系。结论本次调查显示2007年天津市麻疹人群抗体GMC总体保持在较高水平。风疹、流行性腮腺炎疫苗接种率和抗体水平较低,2剂次的麻腮风疫苗(MMR)纳入免疫规划既有助于消除麻疹,也有利于控制风疹和流行性腮腺炎。
Objective To understand the levels of measles, rubella and mumps in healthy population in Tianjin and evaluate the need of vaccination. Methods A total of 608 blood samples from 608 healthy people aged 0-57 years were collected from March 2007 to March 2007. The measles, rubella and mumps IgG levels were detected by ELISA. Using linear correlation analysis of antibody positive rate, the protective rate of GMC and the incidence of disease, P <0.05 for the difference was statistically significant. Results The immunization rates of measles, rubella and mumps were 70.39%, 16.78% and 12.34%, respectively. The positive rates of antibodies were 91.78%, 65.79% and 73.52%, respectively. The antibody mean geometric mean concentrations (GMCs) were 2 488.10 IU / L, 200.4 IU / ml and 759.91 U / ml. There was a significant correlation between measles antibody positive rate, protection rate and incidence (P <0.01), but there was no significant correlation between GMC and measles incidence. There was no correlation between the positive rate of rubella and mumps antibody and the incidence of GMC. Conclusion This survey shows that in 2007, the population of GMC in Tianjin measles population remained at a high level. Rubella and mumps vaccination rates and antibody levels are low. The inclusion of 2 doses of MMR into an immunization program can both help to eliminate measles and control rubella and mumps.