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目的观察H型高血压左心室肥厚患者应用依那普利叶酸片治疗对患者心功能的临床效果。方法选取医院收治的1~2级H型高血压左室肥厚患者80例为此次临床观察对象,均接受依那普利叶酸片进行治疗,持续治疗6个月。观察患者经依那普利叶酸片治疗后收缩压与舒张压情况、同型半胱氨酸水平(HCY)情况、左心室二尖瓣血流峰速度及左室射血分数值(LVEF)情况。结果治疗后,患者收缩压、舒张压及HCY水平较治疗前均明显下降(P<0.01);治疗后,患者二尖瓣血流峰速度、LVEF值较治前均升高(P<0.05);80例患者用药治疗期间,出现心悸1例、口干1例、干咳1例,不良反应发生率为3.75%。结论依那普利叶酸片可有效改善H型高血压左室肥厚患者的心功能,具有降血压、降低HCY水平的功效,可改善患者左室舒张功能,值得临床推广应用。
Objective To observe the clinical effect of enalapril folate tablets on cardiac function in patients with Hypertension and left ventricular hypertrophy. Methods A total of 80 patients with H-type hypertensive left ventricular hypertrophy who were admitted to hospital were enrolled in this study. All patients were treated with enalapril folate for 6 months. Systolic and diastolic blood pressure, homocysteine level (HCY), left ventricular mitral flow peak velocity and left ventricular ejection fraction (LVEF) were observed after enalapril folate treatment. Results After treatment, systolic blood pressure, diastolic blood pressure and HCY levels were significantly lower than those before treatment (P <0.01). After treatment, mitral flow peak velocity and LVEF were significantly increased (P <0.05) One patient had palpitations, one patient had dry mouth and one patient had dry cough. The incidence of adverse reactions was 3.75% in 80 patients. Conclusion Enalapril folate tablets can effectively improve the left ventricular hypertrophy in patients with Hypertension heart function, with lower blood pressure, reduce the effect of HCY levels, can improve left ventricular diastolic function in patients with deserved clinical application.