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神经系统与免疫系统通过神经肽、神经递质和细胞因子相互作用。血管活性肠肽(VIP)作为一种重要的神经肽参与炎症反应和免疫应答的调控。近年研究表明VIP能通过与树突状细胞(DC)表面的受体结合调节DC的表型和功能成熟,在DC体内迁移和功能成熟中发挥重要作用。VIP主要通过调节DC膜表面黏附分子和共刺激分子的表达、趋化因子及其受体的表达和趋化活性,诱导Th细胞分化以及抗原提呈功能发挥作用。
The nervous system interacts with the immune system through neuropeptides, neurotransmitters and cytokines. Vasoactive intestinal peptide (VIP) is an important neuropeptide involved in the regulation of inflammatory and immune responses. In recent years, studies have shown that VIP can play an important role in the migration and functional maturation of DC by regulating the phenotype and function of DC by binding to the receptors on the surface of dendritic cells (DCs). VIP mainly through the regulation of DC membrane surface adhesion molecules and costimulatory molecules expression, chemokine and its receptor expression and chemotactic activity induced Th cell differentiation and antigen presentation function play a role.