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目的探讨内皮素在消化性溃疡发病中的作用。方法本文采用放免法测定了５６例胃十二指肠溃疡患者、１０例健康人血浆及组织中的ＥＴ—１含量和其与溃疡面积的相关性．结果在各溃疡组血浆ＥＴ—１的浓度与正常组比较均增高。溃疡活动期，血浆ＥＴ—１浓度与正常组比较明显增高Ｐ＞０．０１，疤痕期浓度降至正常。溃疡边缘粘膜组织ＥＴ—１的含量明显高于自体正常粘膜组织及对照组粘膜组织中的含量。且粘膜组织中ＥＴ—１的含量与溃疡面积呈显著性正相关（ｒ＝０．８５７５，Ｐ＞０．０５）。结论本组试验结果提示，内皮素在消化性溃疡发病机制中可能是一个重要的介质。且与病情的演变有着密切的关系。
Objective To investigate the role of endothelin in the pathogenesis of peptic ulcer. Methods The radioimmunoassay method was used to determine the content of ET-1 in 56 cases of gastroduodenal ulcer and 10 cases of healthy human plasma and its correlation with ulcer area. Results The concentrations of plasma ET-1 in all ulcer groups were higher than those in normal group. Ulcer activity, plasma ET-1 concentration was significantly higher than the normal group P> 0.01, the scar phase decreased to normal. The content of ET-1 in mucosal ulcer margin was significantly higher than that in autologous normal mucosa and control mucosa. The content of ET-1 in mucosal tissue was significantly and positively correlated with ulcer area (r = 0.8575, P> 0.05). Conclusion The results of this group of experiments suggest that endothelin may be an important mediator in the pathogenesis of peptic ulcer. And the evolution of the disease has a close relationship.