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1例6岁男性癫痫患儿,曾先后口服苯妥英钠、拉莫三嗪、丙戊酸钠、苯巴比妥治疗,因不能规律服药致使癫痫反复发作且进行性加重,家属自行给予其口服奥卡西平300 mg、3次/d,上述症状未再发作。但40 d后出现行走不稳、反应迟钝,且癫痫症状也加重。入院诊断为癫痫,全身强直-阵挛发作,奥卡西平致定向力障碍及共济失调。停用奥卡西平,给予丙戊酸钠、还原性谷胱甘肽、维生素C,次日癫痫得到控制。第8天定向力障碍及共济失调消失,癫痫未再发作,遂出院。出院后规律服用丙戊酸钠和氯硝西泮。随访1个月,未再出现癫痫发作、定向力障碍和共济失调。
A 6-year-old male with epilepsy has oral phenytoin sodium, lamotrigine, sodium valproate, phenobarbital treatment, because of irregular medication can cause recurrent seizures and progressive increase in their own family to give oral O Carbamazepine 300 mg, 3 times / d, the above symptoms did not recurrence. However, 40 days after walking instability, unresponsive, and symptoms of epilepsy also increased. Admission diagnosed as epilepsy, generalized tonic-clonic seizures, oroctopine-induced ataxia and ataxia. Discontinue oxcarbazepine, given sodium valproate, reduced glutathione, vitamin C, the next day epilepsy be controlled. Disorder on the 8th day and ataxia disappeared, epilepsy was not repeated attack, then discharged. Regular discharge sodium valproate and clonazepam after discharge. One month follow-up, seizures, disorientation and ataxia did not recur.