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目的:检测细胞间黏附分子-1(ICAM-1)在慢性乙型肝炎患者的表达与病毒复制、肝组织炎症及纤维化程度的关系。方法:采用免疫组织化学方法检测66例慢性乙型病毒性肝炎患者和10例非肝病对照者肝组织中ICAM-1、HBc Ag表达的情况。结果:慢性乙型肝炎患者肝组织中ICAM-1的表达水平均高于正常肝组织(P<0.05);慢性乙型肝炎患者中HBc Ag阳性者ICAM-1蛋白阳性表达率为89.4%,明显高于HBc Ag阴性者42.1%(P<0.01);随着慢性乙型肝炎病理损伤的程度的加重,ICAM-1蛋白的阳性表达率逐渐增高(P<0.01)。结论:ICAM-1参与了慢性乙型肝炎的病理损伤机制;ICAM-1可反映肝炎活动及肝组织损害程度。
Objective: To investigate the relationship between the expression of intercellular adhesion molecule-1 (ICAM-1) and viral replication, hepatic inflammation and fibrosis in chronic hepatitis B patients. Methods: The expression of ICAM-1 and HBc Ag in 66 cases of chronic hepatitis B and 10 cases of non-liver disease were detected by immunohistochemistry. Results: The expression of ICAM-1 in liver tissue of patients with chronic hepatitis B was significantly higher than that of normal liver tissue (P <0.05). The positive rate of ICAM-1 protein in HBcAg-positive patients was 89.4% (P <0.01). The positive rate of ICAM-1 protein increased with the severity of chronic hepatitis B (P <0.01). Conclusion: ICAM-1 is involved in the pathological mechanism of chronic hepatitis B. ICAM-1 can reflect the activity of hepatitis and the extent of liver damage.