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目的探析他汀类药物对冠心病经皮冠状动脉介入治疗(PCI)干预患者血脂及心血管事件风险的影响。方法 93例冠心病PCI干预患者,按照随机数字表法分为A组(47例)与B组(46例)。两组均在常规治疗基础上予以他汀类药物治疗,A组采取他汀序贯治疗,B组采取他汀常规治疗,比较两组治疗前后血脂指标[胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]及心血管事件发生率(心肌梗死、卒中、心功能衰竭、血运重建、死亡)。结果两组治疗前各项血脂指标比较差异均无统计学意义(P>0.05);治疗后A组TG、TC、LDL-C均低于B组,HDL-C高于B组(P<0.05)。A组心血管事件发生率为6.4%(3/47),与B组的13.0%(6/46)比较差异无统计学意义(P>0.05)。结论他汀序贯治疗在冠心病PCI术患者中应用,可有效发挥强化降脂效果,使患者获益,疗效佳,值得推广借鉴。
Objective To investigate the effect of statins on the risk of blood lipids and cardiovascular events in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). Methods Ninety - three patients with coronary artery disease under PCI were divided into group A (n = 47) and group B (n = 46) according to random number table. Both groups were treated with statins on the basis of routine treatment. A group received sequential treatment with statins, and B group received routine treatment with statins. The levels of serum lipid (TC, triglyceride, TG, (LDL-C, HDL-C) and the incidence of cardiovascular events (myocardial infarction, stroke, heart failure, revascularization, death). Results The levels of TG, TC and LDL-C in group A were lower than those in group B and HDL-C were higher than those in group B after treatment (P <0.05) ). The incidence of cardiovascular events in group A was 6.4% (3/47), which was not significantly different from 13.0% (6/46) in group B (P> 0.05). Conclusions The sequential treatment of statins in coronary artery disease patients with PCI, which can effectively enhance the lipid-lowering effect, so that patients benefit, good effect, it is worth promoting reference.