Objective:To observe the intervention influence and effect of simvastatin on the expression of interleukin 17(L117),high mobility group protein 1(HMGB1)and TLR4 path in Lupus nephritis(LN)rats.Methods:A total of 28 BSXSB male mice with LN(16 weeks)were randomlv divided into observation group and the comparison group,observation group was given 6 mg·kg~(-1)·d~(-1)simvastatin in 0.1%PBS lavage for 4 weeks.the comparison group was not given any trestment.Blood urea nitrogen(BUN)level and urine trace albumin(Scr)level of two groups were determined.The expression of IL17.HMGB1 and TLR4 protein was detected using immune histochemical method,and the kidney histological damage was observed.Results:BNU,LI17.HMGB1,TLR4protein and HMGB1 mRNA in observation group was significantly lower than that in control group(P<0.05):There was no statistical difference of Scr level between two goups(P<0.05).Histological observation showed glomerular lesions integral of observation group was obviously lower than that of control group.Conclusions:Simvastatin can reduce the expression of IL17.HMGB1 and TLR4 protein in LN mice,thereby can inhibit the autoimmune response as a potential treatment function of LN. Objective: To observe the effect of simvastatin on the expression of interleukin 17 (L117), high mobility group protein 1 (HMGB1) and TLR4 path in Lupus nephritis (LN) rats. Methods: A total of 28 BSXSB male mice with The comparison group LN (16 weeks) were randomly divided into observation group and the comparison group, the observation group was given 6 mg · kg -1 · d -1 simvastatin in 0.1% PBS lavage for 4 weeks. The comparison group was not given any trestment. Blood urea nitrogen (BUN) level and urine trace albumin (Scr) levels of two groups were determined. The expression of IL17. HMGB1 and TLR4 protein was detected using immune histochemical method, and the kidney histological damage was observed. Results: BNU, LI17.HMGB1, TLR4protein and HMGB1 mRNA in observation group was significantly lower than that in control group (P <0.05): There was no statistical difference of Scr level between two goups (P <0.05) .Histological observation showed glomerular lesions integral of observation group was obviously lower t han that of control group. Conclusions: Simvastatin can reduce the expression of IL17. HMGB1 and TLR4 protein in LN mice, can inhibit the autoimmune response as a potential treatment function of LN.