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近年来,已经报道了许多表现为胃分化的良性和恶性宫颈腺性病变,但胃型腺癌前病变尚未进行充分研究。本研究报道9例罕见的原位宫颈腺癌(AIS),其人乳头状瘤病毒(HPV)阴性而呈现胃型分化伴部分肠分化。患者为25~73岁女性,平均年龄51岁。所有病变均位于(或恰好靠近)子宫颈移形带,3例病变向子宫下段延伸,其中2例累及子宫内膜。9例中,正常的宫颈腺体结构在很大程度上得以保留,其中5例宫颈腺体结构复杂程度轻度增加。腺体上皮呈胃型(4例)和胃-肠混合型
In recent years, many benign and malignant cervical glandular lesions, which manifest as gastric differentiation, have been reported, but gastric glandular precancerous lesions have not been adequately studied. This study reported 9 cases of rare in situ cervical adenocarcinoma (AIS), the human papillomavirus (HPV) negative and showed gastric differentiation with partial intestinal differentiation. Patients were 25 to 73-year-old female, mean age 51 years. All lesions were located in (or just close to) the cervical metastasis zone, 3 lesions extended to the lower uterine segment, of which 2 involved the endometrium. Nine cases, the normal structure of the cervical gland to a large extent retained, including five cases of cervical gland structure complexity increased slightly. Gland epithelium was gastric (4 cases) and stomach - intestine mixed type