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把癌生长看作癌细胞和正常细胞相互竞争的过程。把生态学中的Lotka-Volterra模型和我们提出的单竞争因子模型用于癌生长和转移的理论研究。着重分析了癌转移阶段的侵害性和器官特异性。在单竞争因子模型中,“最低资源需求量”是唯一的竞争因子,癌细胞具有低于正常细胞的最低资源需求量,是它在竞争中获胜的原因。由于参与竞争两种群的最低资源需求量不仅由它们本身的细胞性质,而且由它们的相互作用决定,所以癌转移表现出对某些器官的特异性。
Think of cancer growth as a process in which cancer cells and normal cells compete with each other. We use the Lotka-Volterra model in ecology and our single-competitive factor model for the theoretical study of cancer growth and metastasis. Emphasis was placed on the invasiveness and organ specificity of the metastatic stage of cancer. In the single-competition model, “minimum resource demand” is the only competitive factor. Cancer cells have the lowest resource requirements below normal cells, which is the reason why it wins the competition. Since the minimum resource requirements of the two groups involved in competition are determined not only by their own cellular properties but also by their interaction, cancer metastases exhibit specificity for certain organs.