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目的通过分析肾病综合征患者代谢激素水平与脂蛋白(α)[Lp(α)]的关系,探讨肾病综合征的代谢激素影响机体脂代谢的途径。方法测定59例肾病综合征患者代谢激素指标血甲状腺激素、胰岛素及Lp(α),分析它们之间的关系,并与60例正常人比较。结果肾病综合征组血游离T3、游离T4、空腹胰岛素及Lp(α)分别为(5.4±2.0)pmol/L、(16±7)pmol/L、(13±5)m IU/L、(1 270±582)mg/L,游离T3、T4均低于正常对照组,空腹胰岛素水平高于对照组,差异均有统计学意义。肾病综合征患者血Lp(α)与游离T3、游离T4呈负相关(r值分别为-0.685、-0.512,均P<0.01)。结论肾病综合征患者存在代谢激素紊乱状态,代谢激素可能通过引起Lp(α)代谢紊乱,间接对心血管系统产生不利影响。
OBJECTIVE: To investigate the relationship between metabolic hormone levels and lipoprotein (α) [Lp (α)] in patients with nephrotic syndrome and to explore the pathways by which metabolic hormones of nephrotic syndrome affect the lipid metabolism of the body. Methods Metabolic hormones, thyroid hormones, insulin and Lp (α) were measured in 59 patients with nephrotic syndrome. The relationship between them was analyzed and compared with 60 normal subjects. Results The levels of free T3, free T4, fasting insulin and Lp (α) in the nephrotic syndrome group were (5.4 ± 2.0) pmol / L and (16 ± 7) pmol / L and 1 270 ± 582) mg / L, free T3, T4 were lower than the normal control group, fasting insulin levels were higher than the control group, the differences were statistically significant. Nephrotic syndrome blood Lp (α) and free T3, free T4 was negatively correlated (r values were -0.685, -0.512, all P <0.01). Conclusion There are metabolic hormone disorders in patients with nephrotic syndrome. Metabolic hormones may cause adverse effects on the cardiovascular system indirectly by causing metabolic disorder of Lp (α).