论文部分内容阅读
目前对开发粘附制剂用于药物的控释或经膜吸收使起到局部治疗作用或促使肽类和在胃肠道吸收差的药物起全身治疗作用是个令人感兴趣的课题。粘膜粘附制剂药物释放的靶部位有眼、胃肠道、宫腔、阴道、口腔和鼻腔。目前已开发的粘膜粘附制剂有软膏、片剂、微粒、液剂和医用绷带等。粘膜粘附材料主要由能形成氢键基团如羧基等亲水性大分子物质组成。该材料在水化过程中呈粘附性质,其主要缺点如下:1.过度水化可能形成易滑脱的粘液;2.粘膜粘附组分的溶胀和水化可能破坏制剂多层结构的完整性。所以对骨架型的粘膜粘附制剂尤感兴趣。许多粘膜粘
The current development of adhesive preparations for the controlled release of drugs or absorption through the membrane to play a local therapeutic effect or to promote the absorption of peptides and drugs in the gastrointestinal tract from the role of systemic treatment is an interesting subject. Mucosal Adhesion Preparation Drug release target sites are the eyes, gastrointestinal tract, uterine cavity, vagina, mouth and nasal cavity. Has been developed mucoadhesive preparations ointment, tablets, particles, liquid and medical bandages. The mucoadhesive material is mainly composed of hydrophilic macromolecular substances capable of forming hydrogen bonding groups such as carboxyl groups. The material has an adhesive nature during hydration, with the following major disadvantages: 1. Over-hydration may form sloughing slime; 2. Swelling and hydration of the mucoadhesive components may disrupt the integrity of the multi-layer structure of the formulation . Therefore, the skeleton-type mucoadhesive preparation is particularly interested. Much mucoadhesion