为比较β1、β2和β3肾上腺素受体亚型阻滞剂对淋巴细胞β受体的亲和力，采用放射性配基3H－DHA、3H－CGP和125I－pindolol对人外周循环血淋巴细胞进行受体结合分析。结果发现，β2受体亚型阻滞剂的受体拮抗效应最强，β3受体亚型阻滞剂具有一定的受体拮抗效应，β1受体亚型阻滞剂的受体拮抗效应最弱，而非选择性β受体阻滞剂普萘洛尔的两种对映体S（－）型和R（＋）型的受体亲和力相差只有3～10倍。提示淋巴细胞β受体以β2亚型为主，β1亚型较少，而且可能存在β3亚型。 To compare the affinity of beta 1, beta 2, and beta 3 adrenergic receptor subtype blockers for lymphocyte beta receptors, radioactive ligands 3H-DHA, 3H-CGP and 125I-pindolol were used to effect human peripheral blood circulating lymphocytes Binding analysis. The results showed that β2 receptor subtype blockers had the strongest antagonist effect, β3 receptor subtype blockers had some receptor antagonistic effects, β1 receptor subtype blockers had the weakest receptor antagonistic effect , While the receptor affinity of the two enantiomer S (-) and R (+) forms of propranolol, which is not the selective β-blocker, differed only by 3 to 10 times. Tip Lymphocyte β receptor subtype β2, β1 subtype less, and there may be β3 subtypes.