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心绞痛这一临床症状早在两个世纪以前就已被清楚地描述,但直至最近10余年,它的病理生理研究才有了较大进展,治疗方法也随之增多。冠状动脉发生病变,它所能输送的氧相应减少。若减少至低于心肌耗氧量,就发生缺血性心绞痛。治疗的成功,就在于增加冠状动脉对缺血区的供血或减少心肌耗氧量。近百年来治疗心绞痛一直沿用硝酸甘油,直到目前它仍是临床应用最广泛的短效抗心绞痛药。在
As early as two centuries ago, the clinical symptoms of angina have been clearly described. However, until recently, pathophysiology has made great progress and the treatment methods have also increased. Coronary artery disease, it can reduce the amount of oxygen delivered. If reduced to less than myocardial oxygen consumption, ischemic angina occurred. The success of treatment is to increase coronary blood flow to the ischemic area or reduce myocardial oxygen consumption. In the past hundred years, nitroglycerin has been used in the treatment of angina, until now it is still the most widely used short-acting anti-anginal drug in clinical practice. in