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核组蛋白H2A,H2B,H3和H4为一组带正电荷的核蛋白,由带负电荷的DNA呈螺旋状围绕。组蛋白经广泛的翻译后修饰,可能影响染色质高级结构的组成与稳定,后者在控制转录与细胞周期中具重要作用。已证实多种自身免疫与血管疾病中存在抗组蛋白抗体且与某些严重的或有并发症的疾病有
The nuclear histones H2A, H2B, H3 and H4 are a group of positively charged nuclear proteins that are helically surrounded by negatively charged DNA. The extensive post-translational modification of histones may affect the composition and stability of chromatin-like higher-order structures, which play an important role in controlling transcription and cell cycle. A variety of autoimmune and vascular diseases have been identified in the presence of anti-histone antibodies and with some serious or complications of the disease there