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目的:研究Survivin和p53蛋白在前列腺癌组织的 表达及生物学意义,并探讨其相关性.方法:采用免疫组化的 方法检测55例前列腺癌组织中Survivin和p53蛋白的表达. 结果:Survivin和p53蛋白在前列腺癌组织中的阳性表达例数 分别为43(78.18%)和27(49.09%),并且均与肿瘤的病理 学分级、临床分期相关(P<0.05).在前列腺癌中两种蛋白的 表达密切相关(r=0.629).结论:Survivin蛋白的表达和p53 突变对凋亡抑制的协同作用可能在前列腺癌的发生发展过程 中起关键作用.
Objective: To investigate the expression and biological significance of Survivin and p53 protein in prostate cancer tissues and to explore its correlation.Methods: Survivin and p53 protein expressions were detected by immunohistochemistry in 55 cases of prostate cancer.Results: Survivin and The positive expression rates of p53 protein in prostate cancer tissues were 43 (78.18%) and 27 (49.09%), respectively, which were all related to the pathological grade and clinical stage (P <0.05) (R = 0.629) .Conclusion: The synergistic effect of Survivin protein expression and p53 mutation on apoptosis inhibition may play a key role in the development of prostate cancer.