基于关联规则和复杂系统熵聚类的骨折术后中药熏洗方的用药规律研究

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目的:分析骨折术后中药熏洗方的用药规律.方法:通过中国知网、维普、万方、中国生物医学文献数据库搜集2011-2016年文献中骨折术后中药熏洗处方,采用TCMISS中医传承辅助平台软件提取分析处方中各药物的使用频次、四气、五味、归经、归类以及药物之间的关联规则等.结果:对212个中药处方进行分析,使用频率较高的中药有红花、伸筋草、透骨草、牛膝、乳香、威灵仙、海桐皮、没药、当归、桂枝、川乌、木瓜、艾叶、防风等.药物的四气分布主要为温、平,五味分布主要为辛、苦、甘,归经分布主要为肝、肾、脾.药物归类分布主要为伞形科、毛茛科、菊科.红花、伸筋草、透骨草、牛膝、乳香、威灵仙、海桐皮、没药、当归、桂枝等均为骨折术后中药熏洗方最常用的中药.结论:骨折术后中药熏洗方以“活血化瘀止痛、祛风湿通经络、兼顾补血”为主要治法;核心药物是红花、伸筋草、透骨草、牛膝、乳香、威灵仙、海桐皮、没药、当归、桂枝;关键药物组合是“红花与透骨草”;处方用药以“活血化瘀止疼痛,祛风散湿通经络,行血补血生新血”为则.“,”Objective:To analyze the medication rule in herbal fumigate-washing prescriptions for postoperative period of fracture.Methods:Herbal fumigate-washing prescriptions for postoperative period of fracture were searched from Chinese National Knowledge Infrastructure,VIP database,Wanfang database and Chinese Biomedical Database,from 2011 to 2016.We used Chinese medicine inheritance support system (TCMISS) to analyze the frequency,four natures,five flavors,meridian entry,plant classification of drugs,and the association rules between drugs.Results:Based on the analysis of 212 herbal fumigate-washing prescriptions,herbs used with high frequency were Honghua (Flos Carthami),Shenjincao (Lycopodium Clavatum),Tougucao (Tuberculate Speranskia Herb),Niuxi (Radix Achyranthis Bidentatae),Ruxiang (Frankincense),Weilingxian (Radix Clematidis),Haitongpi (Cortex Erythrinae),Moyao (Myrrh),Danggui (Angelica Sinensis),Guizhi (Ramulus Cinnamomi),Chuanwu (Aconitum Carmichaeli),Mugua (Fructus Chaenomelis Lagenariae),Aiye (Folium Artemisiae Argyi),Fangfeng (Radix Sileris),et al.Four natures of drugs were mainly consist of warmth and neutral.Five flavors of drugs were mainly consist of pungent,bitter and sweet.Meridian entrys were mainly consist of liver,kidney and spleen.Plant classification of drugs were mainly consist of Flos Carthami,Lycopodium Clavatum,Tuberculate Speranskia Herb,Radix Achyranthis Bidentatae,Frankincense,Radix Clematidis,Cortex Erythrinae,Myrrh,Angelica Sinensis,Ramulus Cinnamomi,.were the most common herbal fumigate-washing prescriptions for postoperative period for fracture.Conclusion:The main principles of herbal fumigate-washing prescriptions for postoperative period for fracture is promoting blood circulation for removing blood stasis and relieving pain,dispelling wind-damp and keeping main and collateral channels smooth,and enriching the blood.The key medition are Flos Carthami,Lycopodium Clavatum,Tuberculate Speranskia Herb,Radix Achyranthis Bidentatae,Frankincense,Radix Clematidis,Cortex Erythrinae,Myrrh,Angelica Sinensis,Ramulus Cinnamomi.The key drug combination are Flos Carthami and Tuberculate Speranskia Herb.We emphasize the medication principle that the medicine should promote blood circulation for removing blood stasis and relieving pain,dispel wind damp and keep main and collateral channels smooth,remove and enrich the blood to promote the formation ofnew blood.
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