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冠状病毒(coronavirus, CoV)是一类广泛存在的、可引起人类疾病的传染病病原体，是威胁我国以及全世界公共卫生安全的重要隐患。已有越来越多的证据表明，能感染人的7种冠状病毒均为动物源性，通过跨种传播而最终感染人。这些不可预测、但不断发生的冠状病毒反复跨种传播事件已经引起全世界对冠状病毒的特别关注以及恐慌。目前普遍认为刺突蛋白(spike, S)是冠状病毒入侵、实现跨种传播的关键因素。本文聚焦于近年来新发现的且具有潜在跨种传播能力的冠状病毒，总结和分析S蛋白介导的病毒入侵及潜在跨种传播机制的研究进展，为应对潜在的新型冠状病毒跨种传播事件提供有效的防控策略，对传染病防控的公共卫生实践具有一定意义。“,”Coronaviruses (CoVs) are a group of common viruses that can infect humans and pose a great threat to global public health. Mounting evidence has shown that seven zoonotic CoVs can infect human through cross-species transmission. These continuously occurring yet unpredictable events of CoVs repeatedly crossing species barriers have attracted special attention to CoVs and caused panic worldwide. It is generally believed that the spike (S) protein is the key factor determining the cross-species transmission and the invasion potential of CoVs. This review focused on the new-found coronaviruses with potential cross-species transmission capabilities, and summarized and analyzed the research progress in S protein-mediated viral invasion as well as the potential mechanisms, aiming to provide reference for developing effective prevention and control strategies against potential cross-species transmission of CoVs in the future.