钩端螺旋体脑膜脑炎专题报道不多,现就资料比较完整的4例讨论其诊断问题和发病机制治疗问题。临床资料4例患者中男3例,女1例;年龄在19～33岁之间,均于6～7月间发病,起病除1例较缓外,余均较急。主要症状为发热、头痛、全身衰竭、呕吐、项强直、克氏征等。病程:2例5天,2例9～10 Leptospiral meningoencephalitis few reports, now more complete information on the 4 cases to discuss its diagnosis and pathogenesis of treatment problems. Clinical data 4 patients in 3 males and 1 female; aged 19 to 33 years old, were in the disease between June and July, onset except 1 case of more slowly, I was more urgent. The main symptoms are fever, headache, systemic failure, vomiting, tetanus, Kirschner sign and so on. Course of disease: 2 cases 5 days, 2 cases 9 to 10