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目的探讨慢性乙型病毒性肝炎(chronic viral hepatitisB)(慢乙肝)患者血清锰超氧化物歧化酶(manganese superoxide dismutase,MnSOD)和硝基酪氨酸(nitrotyrosine,NT)水平的变化。方法选择慢乙肝患者40例,健康对照组20例,应用酶联免疫吸附试验检测血清NT水平,黄嘌呤氧化酶法检测血清MnSOD水平。结果慢性乙型病毒性肝炎患者与对照组相比,NT浓度升高,MnSOD浓度降低(P<0.05)。差异有统计学意义。结论慢性乙型病毒性肝炎患者存在NT、MnSOD水平的变化,说明慢性乙型病毒性肝炎患者体内存在氧化抗氧化反应,有氧化应激的发生。
Objective To investigate the changes of serum manganese superoxide dismutase (MnSOD) and nitrotyrosine (NT) in patients with chronic viral hepatitis B (chronic hepatitis B). Methods Forty patients with chronic hepatitis B and 20 healthy controls were enrolled in the study. Serum NT level was measured by enzyme linked immunosorbent assay (ELISA), and serum MnSOD level was measured by xanthine oxidase method. Results Compared with the control group, the concentration of NT increased and the concentration of MnSOD decreased in patients with chronic hepatitis B (P <0.05). The difference was statistically significant. Conclusion There are changes of NT and MnSOD levels in patients with chronic hepatitis B, indicating the presence of oxidative and anti-oxidative reactions and the occurrence of oxidative stress in patients with chronic hepatitis B virus.