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目的 探讨增殖细胞核抗原 (PCNA)、抑癌基因的突变蛋白 (p5 3)在喉癌中的表达及临床意义。 方法采用免疫组化S -P法 ,对 5 8例喉癌和 10例喉正常组织检测 ,用有关统计学方法结合临床及随访资料进行分析。结果 5 8例喉癌中 ,PCNA、p5 3蛋白阳性率分别为 72 .41% (4 1/ 5 8)和 5 1.72 % (30 / 5 8)。正常组织染色阴性。喉癌组织分化、临床分期、有无淋巴结转移和复发与PCNA、p5 3阳性表达率有关。 结论 PCNA、p5 3蛋白的过度表达与喉癌预后有关
Objective To investigate the expression and clinical significance of proliferating cell nuclear antigen (PCNA) and tumor suppressor gene mutein (p5 3) in laryngeal carcinoma. Methods The immunohistochemical S-P method was used to detect the normal tissue of 58 laryngeal cancer patients and 10 laryngeal squamous cell carcinoma patients. The statistical methods were used to analyze the clinical and follow-up data. Results The positive rates of PCNA and p5 3 in 58 cases of laryngeal carcinoma were 72.41% (4 1/5 8) and 5 1.72% (30/58), respectively. Normal tissue staining negative. Laryngeal cancer tissue differentiation, clinical stage, with or without lymph node metastasis and recurrence and PCNA, p5 3 positive expression rate. Conclusion The overexpression of PCNA and p5 3 proteins is related to the prognosis of laryngeal carcinoma