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本实验在建立 DIC 高凝期模型的基础上,选用凝血、纤溶、血液流变、球结膜微循环、病理形态学及动物病死率等指标,探讨中医凉血化瘀药作用原理。实验结果表明:凉血药与活血化瘀药配伍,对大肠杆菌内毒素诱导家兔 DIC 高凝期有预防作用,对高凝期上述各指标均表现有不同程度的改善,提示其主要作用环节在于改善高凝期这一时相的病理变化。
In this experiment, based on the establishment of DIC hypercoagulability model, selection of coagulation, fibrinolysis, hemorheology, bulbar conjunctiva microcirculation, pathological morphology and animal mortality and other indicators to explore the role of traditional Chinese medicine in cooling blood and medicine. The experimental results show that: compatibility of Liangxue and blood circulation phlegm drugs, E. coli endotoxin induced DIC hypercoagulability period in rabbits has a preventive effect on the high coagulation period of the above indicators have shown varying degrees of improvement, suggesting that the main role of the link It is to improve the pathological changes of the hypercoagulability phase.