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本文对３０例癌症患者放疗前、首次放疗和继续放疗后血清中的脂质过氧化物（ＬＰＯ）、β－胡萝卜素（β－Ｃａｒ）、维生素Ｅ（Ｖ＿Ｅ）、超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）进行了测定。结果表明，癌症患者放疗后血中ＬＰＯ含量明显高于放疗前（Ｐ＜０．０１），β－Ｃａｒ和Ｖ＿Ｅ含量减少（Ｐ＜０．０１），ＳＯＤ活性下降（Ｐ＜０．０１），ＧＳＨ－Ｐｘ活性增高（Ｐ＜０．０５）。继续接受放疗后，ＬＰＯ含量随放射剂量增加而增多（Ｐ＜０．０１），Ｖ＿Ｅ含量明显减少（Ｐ＜０．０５），β－Ｃａｒ含量减少，但差异不显著，ＳＯＤ随放射剂量增加而递减（Ｐ＜０．０１），ＧＳＨ－Ｐｘ活性由增高转为降低（Ｐ＜０．０１），表明随辐射剂量增加，抗氧化剂含量下降，脂质过氧化作用增强，这为抗氧化剂作为临床抗辐射药物提供了依据。
In this paper, the serum levels of lipid peroxides (LPO), beta-carotene, vitamin E (V_E) and superoxide dismutase (SOD) in 30 cancer patients before and after radiotherapy and continuous radiotherapy ) And glutathione peroxidase (GSH-Px) were measured. The results showed that the level of LPO in the cancer patients after radiotherapy was significantly higher than that before radiotherapy (P <0.01), the content of β-Car and V_E decreased (P <0.01) and the activity of SOD decreased (P <0.01) GSH-Px activity increased (P <0.05). After continued radiotherapy, LPO content increased with the increase of radioactive dose (P <0.01), V_E content decreased significantly (P <0.05), β-Car content decreased, but the difference was not significant, SOD increased with the dose (P <0.01). The GSH-Px activity decreased from increased to decreased (P <0.01), indicating that with the increase of radiation dose, the content of antioxidants decreased and the lipid peroxidation increased. Anti-radiation drugs provide the basis.