论文部分内容阅读
由于乙型肝炎病毒(HBV)、艾滋病病毒(HIV)具有相同的传播途径,HBV在感染HIV人群中的发生率较普通人群更高,在中国HBV高流行区域表现尤为明显。由于HIV和HBV合并感染会造成疾病进展加快,肝硬化、终末期肝病发生率较单纯HBV感染者更高。对于合并HBV之HIV感染者,若不开始抗反转录病毒治疗(ART)而单纯治疗HBV感染,用药需要注意避免诱发HIV耐药。开始ART时,用药选择宜兼顾HBV,治疗过程中若要换药,亦须保留对HBV有效之治疗用药。
Because Hepatitis B virus (HBV) and HIV (HIV) have the same route of transmission, HBV is more commonly found in the HIV-infected population than in the general population, especially in areas with high HBV prevalence in China. Due to HIV and HBV coinfection will result in accelerated disease progression, cirrhosis, end-stage liver disease incidence higher than those infected with HBV alone. In HIV-infected patients with HBV, treating HBV infection simply without starting anti-retroviral therapy (ART) requires careful attention to avoid inducing HIV-resistance. At the beginning of ART, the choice of medication should take into account the HBV, to change the course of treatment, but also to retain the effective treatment of HBV medication.