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目的观察紫杉醇脂质体与奥沙利铂、5-氟尿嘧啶联合方案(POF方案)治疗晚期食管癌的临床效果。方法 70例晚期食管癌患者为研究对象,将其随机分为观察组与对照组,各35例。观察组给予紫杉醇脂质体与奥沙利铂、5-氟尿嘧啶联合治疗,对照组给予常规化疗(奈达铂),比较两组治疗效果。结果观察组总有效率为57.1%,对照组总有效率为28.6%,观察组总有效率显著高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论紫杉醇脂质体与奥沙利铂、5-氟尿嘧啶联合治疗晚期食管癌的临床效果显著,值得在临床上推广。
Objective To observe the clinical effect of paclitaxel liposome combined with oxaliplatin and 5-fluorouracil (POF) in the treatment of advanced esophageal cancer. Methods Seventy patients with advanced esophageal cancer were randomly divided into observation group and control group with 35 cases in each group. The observation group was treated with paclitaxel liposomes combined with oxaliplatin and 5-fluorouracil, and the control group was given conventional chemotherapy (nedaplatin). The therapeutic effect was compared between the two groups. Results The total effective rate was 57.1% in the observation group and 28.6% in the control group. The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group The difference was not statistically significant (P> 0.05). Conclusion paclitaxel liposomes combined with oxaliplatin, 5-fluorouracil in the treatment of advanced esophageal cancer has a significant clinical effect and is worthy of clinical promotion.