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目的了解中国西部地区人类免疫缺陷病毒(HIV)感染者性伴侣对艾滋病暴露前用药(PrEP)的接受意愿调查情况,探讨接受意愿不同的主要影响因素。方法于2009年10月—2010年6月在中国西部的四川省和新疆维吾尔族自治区,采用方便抽样方法招募了473名HIV感染者性伴进行PrEP接受意愿调查。结果 473名调查者的PrEP接受意愿平均得分为(4.16±1.23)分,其中57.29%(271/473)明确表示完全能接受,23.04%(109/473)表示也许能接受,4.02%(19/473)表示不太清楚,9.94%(47/473)表示不太能接受,5.71%(27/473)表示完全不能接受;在最近半年里,发生过性行为的占83.51%(395/473),在发生性行为时能坚持每次都使用安全套的占72.66%(287/395),28.54%(135/473)的人现在患有或者曾经患过性病,仅6.77%(32/473)自报曾经使用过毒品,86.05%(407/473)做过HIV病毒检测;对于艾滋病是否会给自己和家人造成威胁,22.84%(107/473)表示完全不担心,63.96%(300/473)表示有一点担心,13.22%(62/473)非常担心;多因素logistic回归分析结果表明,接受PrEP的影响因素为既往性病史和对艾滋病给自己和家人带来威胁的担心程度,有性病史的HIV感染者性伴侣PrEP接受意愿较高,非常担心和有一点担心艾滋病给自己和家人造成威胁的HIV感染者性伴侣PrEP接受意愿均高于不担心者。结论 PrEP在中国西部地区的HIV感染者性伴侣中是可以接受的。
Objective To investigate the willingness to accept pre-exposure prophylaxis (PrEP) of sexual partners of HIV-infected persons in western China and to explore the main influencing factors of different willingness to accept. Methods From October 2009 to June 2010, 473 HIV-infected sexual partners were enrolled in Sichuan Province of western China and Uygur Autonomous Region in Xinjiang Uygur Autonomous Region by random sampling method to investigate the willingness to accept PrEP. Results The mean PrEP willingness of 473 respondents was (4.16 ± 1.23) points, of which 57.29% (271/473) clearly indicated that they were completely acceptable, 23.04% (109/473) said they could accept, 4.02% 473) indicated that it was not clear, 9.94% (47/473) said it was not acceptable, 5.71% (27/473) said totally unacceptable, and 83.51% (395/473) had had sex during the last six months , 72.66% (287/395), 28.54% (135/473), who can consistently use condoms when having sex, are now suffering from or have had STD, only 6.77% (32/473) Reported that they had used drugs and 86.05% (407/473) did HIV virus tests. Whether AIDS posed a threat to themselves or their families, 22.84% (107/473) said they were completely worried and 63.96% (300/473) said A little bit worried that 13.22% (62/473) were very worried about; multivariate logistic regression analysis showed that the factors that influenced the acceptance of PrEP were the past history and the degree of fear of HIV / AIDS to themselves and their families, HIV Infected sexual partners PrEP higher willingness to accept, very worried and a little worried about AIDS for themselves and their families threatened HIV infected partner PrEP Wishes were higher than those who do not worry. Conclusions PrEP is acceptable in HIV-infected sexual partners in western China.