病毒是一类最原始的能自我复制和在宿主细胞内寄生的非细胞生物。自从第一个核苷类药物磺苷(IDU)被用于治疗疱疹性角膜炎获得成功以来,抗病毒化学疗法取得了相当大的进展。目前,最有成效、最活跃的领域是对核苷类化合物的改造,核苷类化合物可改造的部分主要有碱基、核糖核苷键的构型等方面,这几方面的综述已多见报道,下面仅就磷酸酯类修饰作一概述。 Viruses are the most primitive group of non-cellular organisms that self-replicate and are parasitic in host cells. Antiviral chemotherapy has made considerable progress since the success of the first nucleoside sulfanilic acid (IDU) in the treatment of herpes keratitis. At present, the most effective and active field is the transformation of nucleoside compounds. Some of the nucleoside compounds that can be modified mainly include the configuration of nucleotides and riboside nucleotides. Reported that the following is only an overview of phosphate modification.