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目的：研究大肠癌术前放射免疫治疗及化疗（ 或导向化疗） 对大肠癌组织及细胞的影响。方法：６３ 例大肠腺癌患者随机分成五组。Ａ 组１６ 例，术前肿瘤局部注射１３１Ｉ抗ＣＥＡ 单抗；Ｂ 组１０ 例，术前肿瘤局部注射１３１Ｉ；Ｃ 组７例，术前静脉注射丝裂霉素Ｃ；Ｄ 组１３ 例，术前静脉注射抗ＣＥＡ 单克隆抗体丝裂霉素Ｃ 交连物；Ｅ 组１７ 例术前不注射上述各种药物。其后对所有患者行手术并切取标本进行病理组织学观察。结果：肿瘤组织病理退变（ 坏死） 程度：Ａ 组肿瘤组织病理退变程度１ 级２ 例（１２－５％ ） ，２ 级１０ 例（６２－５ ％ ） ，３ 级４ 例（２５％ ） ；Ｂ 组分别为１ 级６ 例（６０ ％ ） ，２ 级４例（４０ ％ ） ；Ｃ 组分别为１ 级２ 例（２８－６ ％ ） ，２ 级５ 例（７１－４％ ） ；Ｄ 组１ 级２ 例（１５－３ ％ ） ，２ 级７ 例（５３－９ ％ ） ，３ 例４ 例（３０－８％ ） ；Ｅ 组病理退变程度１７ 例（１００－０ ％ ） 均为１ 级。结论：１－ 大肠癌术前放射免疫治疗、化疗（ 或导向化疗） 及局部注射放射性核素１３１Ｉ 均能导致肿瘤细胞退行性变。２－ 肿瘤术前治疗对大肠癌手术切除有利。
Objective: To study the effects of preoperative radioimmunotherapy and chemotherapy (or targeted chemotherapy) on colorectal cancer on colorectal cancer tissues and cells. Methods: 63 patients with colorectal adenocarcinoma were randomly divided into five groups. In group A, 16 patients received local injection of 131Ianti-CEA monoclonal antibody before surgery; 10 patients in group B received local injection of 131I; 7 patients in group C received mitomycin C intravenously before surgery; 13 patients in group D received surgery. The anti-CEA monoclonal antibody-mitomycin C cross-linker was injected before the intravenous injection; 17 patients in the E group were not injected with the above-mentioned various drugs before surgery. All patients were followed by surgery and specimens were taken for histopathological observation. RESULTS: Pathological degeneration (necrosis) of tumor tissue: The pathological degeneration of tumor tissue in group A was grade 2 (12-5%), grade 2 was 10 (62-5 %), and grade 3 was 4 (25%). Group B was 6 patients (60%) in grade 1 and 4 patients (40%) in grade 2. Group C was grade 2 (28-6 %) in grade 2 and grade 5 (71-4%) in grade 2; Two patients were in grade 1 (15-3%), 7 patients in grade 2 (53-9%), and 3 patients in 4 patients (30-8%). The degree of pathological degeneration in group E was 100% (17%). Level 1. Conclusions: Preoperative radioimmunotherapy, chemotherapy (or targeted chemotherapy) and local injection of radionuclide 131I in patients with colorectal cancer can all lead to degeneration of tumor cells. 2- Preoperative treatment of cancer is beneficial to surgical resection of colorectal cancer.