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目的：探讨非小细胞肺癌中 ｃｙｃｌｉｎ Ａ的表达与细胞增殖活性及预后的关系。方法：采用免疫组化法检测 ｃｙｃｌｉｎ Ａ在６０例非小细胞肺癌中的表达，采用流式细胞术分析ＤＮＡ含量。结果：在非小细胞肺癌中 ｃｙｃｌｉｎ Ａ的阳性率为４８．３％（２９／６０），ｃｙｃｌｉｎ Ａ阳性者的Ｓ期细胞比例［（１４．４±３．９）％］明显高于阴性者［（９．４±３．５）％］，ｃｙｃｌｉｎ Ａ的表达与患者预后有关。结论： ｃｙｃｌｉｎ Ａ的表达与肿瘤细胞增殖活性增高密切相关，是判断非小细胞肺癌患者预后的一个可参考指标。
Objective: To investigate the relationship between cyclin A expression and cell proliferation activity and prognosis in non-small cell lung cancer. Methods: Immunohistochemistry was used to detect the expression of cyclin A in 60 cases of non-small cell lung cancer. Flow cytometry was used to analyze the DNA content. Results: The positive rate of cyclin A was 48.3% (29/60) in non-small cell lung cancer, and the proportion of S phase cells [(14.4±3.9)%] was significantly higher in cyclin A positive than in the negative. [(9.4 ± 3.5)%], the expression of cyclin A was related to the prognosis of patients. Conclusion: The expression of cyclin A is closely related to the increase of tumor cell proliferation activity. It is a reference index for judging the prognosis of patients with non-small cell lung cancer.