目的探讨评估鼻咽癌(NPC)预后因素的指标。方法对1992～1994年收治的病理诊断明确,完成全程根治性放疗,随访5年以上的115例NPC放射治疗前活检标本,应用免疫组织化学技术检测nm23-H1癌基因蛋白在NPC组织中的表达情况,并分析nm23-H1的表达与NPC分期、放疗敏感性、生存率、转移复发之间的关系。结果NPC组织中nm23-H1蛋白阳性表达率为47.8%。NPC的分期,淋巴结转移,3、5年生存率及远处转移与nm23-H1蛋白低表达有密切关系。结论nm23-H1蛋白低表达对判断病变进展,预测颈部淋巴结转移的出现趋势、生存率及转移复发和将来可能进行的基因治疗有指导作用和实用意义。 Objective To evaluate the prognostic factors of nasopharyngeal carcinoma (NPC). Methods The pathological diagnosis of 1992 to 1994 was clear, complete radical radiotherapy, followed up for 5 years more than 115 cases of NPC before radiotherapy biopsy specimens, immunohistochemical detection of nm23-H1 oncogene protein in NPC tissue expression The relationship between nm23-H1 expression and NPC staging, radiosensitivity, survival rate, metastasis and recurrence was analyzed. Results The positive rate of nm23-H1 protein in NPC was 47.8%. NPC stage, lymph node metastasis, 3-5 year survival and distant metastasis and nm23-H1 protein expression is closely related. Conclusion The low expression of nm23-H1 protein may play an instructive and practical role in judging the progression of the disease, predicting the appearance of cervical lymph node metastasis, survival rate, metastasis and recurrence and future possible gene therapy.