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目的探讨9号染色体臂间倒位对非正常妊娠的影响。方法确诊9号染色体臂间倒位患者40例作为观察组,并随机选择同期进行婚前检查且随访者40例作为对照组,统计两组发生不孕、早期流产和畸形胎儿几率,分析直系三代(祖辈、父辈及同辈)发生非正常妊娠的几率。结果观察组发生不孕、早期流产几率显著高于对照组(P<0.05),两组发生畸形胎儿的几率比较差异无统计学意义(P>0.05),观察组40例患者中直系三代(祖辈)存在非正常妊娠者34例,二代(父辈)存在非正常妊娠者11例,同辈存在非正常妊娠者3例。结论 9号染色体臂间倒位属于一种染色体的结构变异,其与不孕、早期流产等存在一定相关性。
Objective To investigate the effect of internodal inversion on chromosome 9 on abnormal pregnancy. Methods Confirmed 40 patients with inter-arm inversions on chromosome 9 as the observation group and randomly selected the same period of pre-marital examination and 40 cases of follow-up as a control group, the incidence of infertility, early miscarriage and malformation fetus in both groups were statistically analyzed, Ancestors, fathers and peers) the probability of abnormal pregnancy. Results The incidence of infertility and early miscarriage in the observation group was significantly higher than that in the control group (P <0.05). There was no significant difference in the incidence of malformation fetus between the two groups (P> 0.05) There were 34 cases of abnormal pregnancy, 11 cases of abnormal pregnancy in the second generation (parents), and 3 cases of non-normal pregnancy in the same generation. Conclusion The internodal inversion of chromosome 9 belongs to a structural variation of chromosomes, which has some correlation with infertility and early abortion.