一些较简单的N,N-二烷基取代色胺衍生物如N,N-二甲基及N,N-二乙基色胺(Ⅰ_a,b)均具有强的拟精神活性,5-取代-N,N-二甲基色胺(Ⅰ_c)亦具有明显的中枢作用。考虑到儿茶酚胺(Ⅱ)在体内可被酶氧化为去甲肾上腺素(Ⅲ)。设想在色胺侧链上引入一个β-羟基,亦可能会产生新的具有一定生理活性的化合物。据此,我们合成了一系列β-羟基色胺类化合物(Ⅳ)。 Some of the more simple N, N-dialkyl substituted tryptamine derivatives such as N, N-dimethyl and N, N-diethyltryptamine (Ia, b) N, N-dimethyl tryptamine (Ⅰ_c) also has a significant central role. Considering that catecholamines (II) are enzymatically oxidized to norepinephrine (III) in the body. Imagine the introduction of a beta-hydroxy on the tryptamine side chain, which may also generate new compounds with a certain physiological activity. Accordingly, we synthesized a series of β-hydroxytryptamine compounds (Ⅳ).