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[摘要] 目的 研究一组具有高度敏感性和特异性的血清标记物，能够早期诊断胰腺癌和监测胰腺癌术后疗效。 方法 收集病例100例分为三组，第一组：50例正常人为阴性对照组；第二组：50例经临床确诊为胰腺癌组；第三组：在第二组术后1个月为监测组。然后，分别对它们采取血液进行AFP、CEA、CA199、CA153、CA125及CA50、POA、PCAA的定量检测，研究其阳性率、敏感性和特异性。 结果 第一组的8种指标均为阴性，无显著性差异（P>0.05）。第二组中的8种指标浓度水平明显升高，与第一组相比，具有高敏感性和高特异性，x2值分别为18.7和15.1，具有显著性差异P<0.05。第三组与第二组相比，8种指标浓度水平明显下降至正常水平，P<0.01，具有显著性差异。 结论 当胰腺癌变时，8种相关性指标可作为一组高度敏感性和特异性的血清标记物，同时也可作为胰腺癌术后疗效的一组监测指标。
[关键词] CA50；胰腺癌胚抗原；胰腺癌相关抗原
[中图分类号] R735.9 [文献标识码] B [文章编号] 2095-0616（2013）15-114-03
Clinical research of relativity index with pancreatic cancer prophase and postoperation
GUO Zhaolin LIN Liequan LIN Mingyun
Department of Clinical Laboratory，Dafeng Hospital of Chaoyang District，Shantou 515100，China
[Abstract] Objective To study a group serum markers with high sensitivity and specificity，it can earlydiagnose pancreatic cancer and survey postoperative efficacy of pancreatic cancer. Methods 100 cases were collected and divided into three groups.The first group was nega-tive control group for 50 cases of normal people.The second group was pancreatic cancer group for 50 cases clinically diagnosed to pancreatic cancer.The third group was monitoring group for the second group postoperative one month.Then they were respectively took blood into detect concentration level of AFP，CEA，CA199，CA153，CA125，CA50，POA，PCAA and studied its positive rate， sensitivity and specificity. Results Eight kinds of index in the first group were also negative.The P values were greater than 0.05.They showed no significant difference.Eight kinds of index concentration levels in patients with the second group increas-ed significantly.Compared with the first group，they had high sensitivity and high specificity.The x2 values respectively were 18.7 and 15.1，The P values was inferior to 0.05.They show-ed significant difference.The third group compared with the second group.Eight kinds of index concentration levels significantly decreased to normal level.The P values were also inferior to 0.01.They showed significant difference. Conclusion As pancreas took place canceration eight kinds of correlation index can be used as a group of blood markers with high sensitivity and specificity.At the same time also it can be usedas a group of monitoringindex of pancreatic cancer postoperative efficacy.
[Key words] CA50；Pancreatic antigen；Pancreatic cencer associated antigen
胰腺癌是消化道常见的恶性肿瘤之一，是恶性肿瘤中最常见的，多发生于胰头部。从解剖结构上，胰腺可分为胰头、胰体和胰尾3个部分。胰头和胰体之间的部分称作胰颈[1]。胰头的肿瘤由于靠近胆总管下段，更容易出现由于胆道梗阻造成的黄疸。本研究通过测定胰腺癌患者中血清中AFP、CEA、CA199、CA153、CA125、CA50、POA、PCAA浓度，研究胰腺癌患者术前与术后及及正常人血清中AFP、CEA、CA199、CA153、CA125、CA50、POA、PCAA浓度变化情况。
[关键词] CA50；胰腺癌胚抗原；胰腺癌相关抗原
[中图分类号] R735.9 [文献标识码] B [文章编号] 2095-0616（2013）15-114-03
Clinical research of relativity index with pancreatic cancer prophase and postoperation
GUO Zhaolin LIN Liequan LIN Mingyun
Department of Clinical Laboratory，Dafeng Hospital of Chaoyang District，Shantou 515100，China
[Abstract] Objective To study a group serum markers with high sensitivity and specificity，it can earlydiagnose pancreatic cancer and survey postoperative efficacy of pancreatic cancer. Methods 100 cases were collected and divided into three groups.The first group was nega-tive control group for 50 cases of normal people.The second group was pancreatic cancer group for 50 cases clinically diagnosed to pancreatic cancer.The third group was monitoring group for the second group postoperative one month.Then they were respectively took blood into detect concentration level of AFP，CEA，CA199，CA153，CA125，CA50，POA，PCAA and studied its positive rate， sensitivity and specificity. Results Eight kinds of index in the first group were also negative.The P values were greater than 0.05.They showed no significant difference.Eight kinds of index concentration levels in patients with the second group increas-ed significantly.Compared with the first group，they had high sensitivity and high specificity.The x2 values respectively were 18.7 and 15.1，The P values was inferior to 0.05.They show-ed significant difference.The third group compared with the second group.Eight kinds of index concentration levels significantly decreased to normal level.The P values were also inferior to 0.01.They showed significant difference. Conclusion As pancreas took place canceration eight kinds of correlation index can be used as a group of blood markers with high sensitivity and specificity.At the same time also it can be usedas a group of monitoringindex of pancreatic cancer postoperative efficacy.
[Key words] CA50；Pancreatic antigen；Pancreatic cencer associated antigen
胰腺癌是消化道常见的恶性肿瘤之一，是恶性肿瘤中最常见的，多发生于胰头部。从解剖结构上，胰腺可分为胰头、胰体和胰尾3个部分。胰头和胰体之间的部分称作胰颈[1]。胰头的肿瘤由于靠近胆总管下段，更容易出现由于胆道梗阻造成的黄疸。本研究通过测定胰腺癌患者中血清中AFP、CEA、CA199、CA153、CA125、CA50、POA、PCAA浓度，研究胰腺癌患者术前与术后及及正常人血清中AFP、CEA、CA199、CA153、CA125、CA50、POA、PCAA浓度变化情况。