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成人T细胞淋巴瘤/白血病(ATLL)是与人类T细胞白血病病毒Ⅰ型(HTLV-Ⅰ)相关的T细胞恶性肿瘤。早期ATLL的淋巴细胞存在整合的前病毒HTLV-Ⅰ DNA,而该时特征性组织学改变尚未形成,作者观察了4例早期ATLL的淋巴结改变,患者年龄55～71岁。伴有淋巴结轻度肿大,结内有整合前病毒HTLV-Ⅰ DNA。其淋巴结结构完整,但副皮质肿大,伴有弥漫性中小淋巴细胞浸润,其核稍不规则,无明显核畸形,核仁模糊.胞浆少,可见分裂相,另见少量嗜酸粒细胞和浆细胞浸润。巨细胞聚集成
Adult T-cell lymphoma / leukemia (ATLL) is a T-cell malignancy associated with human T-cell leukemia virus type I (HTLV-I). Early ATLL lymphocytes exist integrated proviral HTLV-Ⅰ DNA, and at this time the characteristic histological changes have not yet formed, the authors observed four cases of early ATLL lymph node changes, patients aged 55 to 71 years. Accompanied by mild lymph node enlargement, the integration of the provirus HTLV-Ⅰ DNA. The lymph node structure is complete, but the secondary cortex enlargement, accompanied by diffuse small and medium lymphocyte infiltration, the nucleus slightly irregular, no obvious nuclear deformity, fuzzy nucleolus. Cytoplasm less visible split phase, see also a small amount of eosinophils And plasma cell infiltration. Giant cells gathered into