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目的:探讨非小细胞肺癌(NSCLC)患者淋巴管生成与胰岛素样生长因子结合蛋白7(IGFBP7)的相关性。方法:免疫组化法检测83例NSCLC手术标本中和10例肺良性病变的Podoplanin、IGFBP7的蛋白表达及其与临床病理的关系。结果:免疫组化结果显示83例NSCLC标本中,IG-FBP7表达阳性59例(71.1%)。IGFBP7阳性肺腺癌组织中的Podoplanin阳性微淋巴管密度为(16.9±6.0),明显高于阴性组(23.1±8.5,P<0.05)。结论:NSCLC中IGFBP7的表达可能与肿瘤的淋巴管生成密切相关。
Objective: To investigate the relationship between lymphangiogenesis and insulin-like growth factor binding protein 7 (IGFBP7) in non-small cell lung cancer (NSCLC). Methods: Immunohistochemistry was used to detect the protein expression of Podoplanin and IGFBP7 in 83 cases of NSCLC and 10 cases of benign pulmonary lesion, and its relationship with clinicopathological features. Results: The results of immunohistochemistry showed that in 83 NSCLC specimens, the positive expression of IG-FBP7 was 59 (71.1%). The Podoplanin positive lymphatic vessel density in IGFBP7 positive lung adenocarcinoma was (16.9 ± 6.0), which was significantly higher than that in negative group (23.1 ± 8.5, P <0.05). Conclusion: The expression of IGFBP7 in NSCLC may be closely related to the lymphangiogenesis of the tumor.