论文部分内容阅读
目的：研究ＨｐｕＩｇＭ检测对儿童胃ＨＰ感染的诊断价值，并观察药物治疗方案的疗效。方法：采用ＥＬＩＳＡＩ法检测ＨｐｕＩｇＭ，并对确诊胃炎者行胃必治＋阿莫西林＋庆大霉素＋灭滴灵＋吗丁啉２周１疗程的治疗（五联药物），阿莫西林过敏者不用该药（四联药物）。结果：１３２例胃炎者及２８例仅有消化道症状者ＨｐｕＩｇＭ阳性率分别为６６.７０％，３５.７０％，两者间有显著差异（Ｐ＜０.００１），且胃炎各年龄组间阳性率亦有差异；１１２例五联药物及２０例四联药物治疗后ＨＰ根除率分别达９７．３％，７１.４％，两者间无显著差异（Ｐ＞ ０．０５），临床治愈率达７１．４％，７０％。结论：ＥＬＩＳＡ法检测ＨｐｕＩｇＭ诊断儿童胃 ＨＰ感染有较高特异性和敏感性，胃炎者随年龄增大其阳性率增加，五联药物或四联药物治疗儿童ＨＰ感染效果可靠，且以前者最理想。
Objective: To study the diagnostic value of HpuIgM in children with gastric HP infection and to observe the curative effect of the drug treatment regimen. Methods: The ELISA method was used to detect HpuIgM, and the patients diagnosed with gastritis were treated with Weibai + Amoxicillin + Gentamicin + Metromethorphan + Momordin for 2 weeks and 1 course of treatment (Wu Lian Yi), amoxicillin allergy Do not use this medicine (quadruple drug). Results: The positive rates of HpuIgM in 132 cases of gastritis and 28 cases of gastrointestinal symptoms were 66.70% and 35.70% respectively, with significant difference (P <0.001) The positive rates were also different. The eradication rates of HP in 112 cases of five-drug combination and 20 cases of quadruple-drug treatment were 97.3% and 71.4% respectively, with no significant difference (P> 0.05) and clinical cure Rate of 71.4%, 70%. Conclusions: The detection of HpuIgM in children with gastric intrauterine infection is highly specific and sensitive by ELISA. The positive rate of gastritis is increased with age, and the efficacy of five or four drugs in treating childhood HP infection is reliable, and the former is the best .