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用鸡给兔穿透性角膜移植为动物模型，研究异种角膜移植排斥反应的特点及治疗。结果：（１）该移植与同种异体移植排斥反应性质相同，但发生率高、出现较早、反应严重；（２）该移植术后房水中ＰＧＥ２含量的增加、角膜新生血管的出现与排斥反应的发生密切相关；（３）同种异体穿透性角膜移植组术后２０天房水中ＰＧＥ２含量、血清中特异性角膜抗体和外周血淋巴细胞转化程度均高于自体移植组，已潜在有排斥反应因素；（４）异种穿透性角膜移植以细胞免疫应答为主，有体液免疫参与；（５）地塞米松和环孢霉素Ａ可抑制异种角膜移植引起的排斥反应。
Rabbit penetrating keratoplasty was used as an animal model to study the characteristics and treatment of xenograft rejection. Results: (1) The allograft and allograft rejection were of the same nature, but the incidence was high, with an earlier occurrence and severe reaction. (2) The increase of PGE2 in aqueous humor after the transplantation, the appearance and rejection of corneal neovascularization (3) The level of PGE2, serum specific corneal antibody and peripheral blood lymphocyte transformation in allograft keratoplasty group were significantly higher than that of autograft group after 20 days of operation Rejection factors; (4) xenograft keratoplasty cell-based immune response, humoral immunity involved; (5) dexamethasone and cyclosporine A can inhibit heterologous keratoplasty-induced rejection.