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目的探讨银杏叶对进行性肾小球硬化及肾小管－间质损害的防治作用。方法通过检测肾小球硬化指数、单位干重肾组织中羟脯氨酸含量以及肾小管－间质中增殖细胞核抗原（ＰＣＮＡ＋）细胞数三项指标以观察药物的作用。结果银杏叶预防治疗组的肾小球硬化指数和肾小管－间质ＰＣＮＡ＋细胞数均明显低于未治疗的硬化组，治疗组单位干重肾组织内羟脯氨酸含量明显低于硬化组，但高于正常对照组（Ｐ均＜０．０１）。结论银杏叶预防性治疗可以明显减轻肾小球硬化和肾小管－间质损害，但不能完全防止病变的发生
Objective To investigate the preventive and therapeutic effects of Ginkgo biloba on progressive glomerulosclerosis and tubulointerstitial damage. Methods The effects of drugs were observed by measuring glomerular sclerosis index, hydroxyproline content in per unit dry weight kidney tissue, and proliferating cell nuclear antigen (PCNA+) cell number in tubulointerstitial. Results The glomerular sclerosis index and the number of PCNA+ cells in the renal tubular-interstitial cells were significantly lower in the Ginkgo biloba leaf preventive treatment group than in the untreated sclerotic group. The content of hydroxyproline in the unit dry weight kidney tissue in the treatment group was significantly lower than that in the sclerosis group. But higher than the normal control group (P all <0.01). Conclusion Prophylactic treatment of Ginkgo biloba can significantly reduce glomerulosclerosis and tubulo-interstitial lesions, but it can not completely prevent the occurrence of lesions.